CASE OF 23/F WITH VIRAL PYREXIA WITH THROMBOCYTOPENIA

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I have been given this case to solve in an attempt to understand the topic of  " patient clinical data analysis" to develop my competency in reading and comprehending clinical data including history, clinical findings, investigations and come up with diagnosis and treatment plan.

A 23 year old woman , who was a student
Came to the opd with chief complaints of 
1. Fever since 5 days  
2. Generalised body pains and Giddiness since 5 days 
3. Headache since 5 days 
4. Pain abdomen since 3 days 
5. Nausea and vomiting since 1 day

HOPI :
Patient was apparently asymptomatic 5 days back then she developed fever which is of high grade, intermittent associated with chills, sweating, generalised body pains and giddiness ( occasionally on getting up from bed,lasting for few seconds) .Fever relieved on taking medications. No diurnal variations and no associated rash, burning micturition,malena and loose stools 

Headache since 5 days which is diffuse, dull aching type with no aggravating and relieving factors 

Complaints of pain abdomen associated with abdominal discomfort and belching since 3 days ,increased on food intake 

Nausea and vomiting since 1 day , 2 episodes ,non bilious,non projectile,non blood stained  with food particles as content. 

For the above complaints she went to a local hospital ,where she was tested positive for dengue (NS1 Ag + ) with low platelet count (50,000 cells/cumm) and was referred to kims nkp

PAST HISTORY :
No H/O DM, HTN, asthma, TB, CAD, epilepsy 
No past surgical history 
K/c/o PCOS since 5 years and was adviced to have dietary modification
Diagnosed with Small fibroid uterus 2 years back ,took unani medication for 3 months.fibroid got resolved within 3 months
Again after 1 year , fibroid had recurred for which she continued using unani medication till now

PERSONAL HISTORY:
Consumes mixed diet 
Sleep decreased since 5 days 
Appetite reduced since 3 days 
Bowels and bladder movements regular 
No addictions 

FAMILY HISTORY : Not significant.

MENSTRUAL HISTORY:
AOM - 12 years
Before 5 Years
Regular menses,
28 days cycle,3-4 days flow
Uses 3-4 pads/day
Associated with pain and no clots

After 5 years
Irrgeular menses
Cycles irregular, 15 days of flow Sometimes 30 days flow
4/5 pads per day
Associated with clots and pain

GENERAL EXAMINATION :
Patient is conscious, coherent and cooperative 
Moderately built and moderately nourished & dehydrated
No pallor,icterus,clubbing,cyanosis,koilonychia,edema and lymphadenopathy 

VITALS :
Temp: 100 F 
PR: 84 bpm 
BP: 
Supine - 80/50 mm hg 
Standing - 90/60 mm hg 
RR: 22 cpm 
Spo2 - 95% at RA 
GRBS - 124 mg/dl 

SYSTEMIC EXAMINATION 

CARDIOVASCULAR SYSTEM:
Inspection:
Chest wall is bilaterally symmetrical.
No precordial bulge
No visible pulsations, engorged veins, scars, sinuses

Palpation:
JVP: normal
Apex beat: felt in the left 5th intercostal space in the mid clavicular line.

Auscutation:
S1, S2 heard , No murmurs

RESPIRATORY SYSTEM-
Position of trachea: central
Bilateral air entry +
Normal vesicular breath sounds - heard
No added sounds.

PER ABDOMEN:
Abdomen is soft and  tenderness present in the epigastric region .
No organomegaly.
Bowel sounds heard.
No palpable mass or free fluid 

CENTRAL NERVOUS SYSTEM:
Patient is Conscious 
Speech: normal
No signs of Meningeal irritation
Motor & sensory system: normal
Reflexes: present
Cranial nerves: intact

INVESTIGATIONS:

25/08/21 :
HEMOGRAM :
Hb:  12.5 gm/dL 
TLC:  4,500 cells/cu mm 
Neutrophils: 31 % 
Lymphocytes: 60 % 
PCV - 34.7 vol %
MCV - 81.6 fl
MCHC - 36 %
MCH - 29.4 pg
RBC: 4.25 millions/cu mm 
Platelets: 88,000 cells/cu mm 
Blood grouping - O +ve

CUE :
Albumin: nil 
Sugars: nil 
PC: 2-3 
EC: 2-3 
RBC: nil 

RFT : 
Serum creatinine: 0.6 mg/dl 
Urea - 13 mg/dl 
Uric acid - 2.8 mg/dl 
Sodium  - 140 meq/l 
K+ - 3.8 meq/l 
Cl-  102 meq/l 

RBS :119 mg/dl 
RAPID DENGUE :
NS1: Negative
IgM: Negative 
IgG: Negative 

BLOOD FOR M.P STRIP TEST  - Negative 

LFT :
Total bilirubin: 0.91 mg/dl 
Direct bilirubin: 0.20 mg/dl 
SGOT: 80 IU/l 
SGPT: 62 IU/l 
ALP: 104 IU/l 
Total protein: 5.4 gm/dl 
Albumin: 3.1 gm/dl 
A/G: 1.34 

CXR - PA VIEW

ECG

USG :
Gall bladder wall edema 
Mild ascites

26/08/21 :
HEMOGRAM 
Hb - 12.4 gm/dl
TLC:  8,100 cells/cu mm 
Neutrophils: 19 % 
Lymphocytes: 73 % 
PCV - 35.5 vol %
MCV - 82.4 fl
MCHC - 34.9 %
MCH - 28.8 pg
RBC: 4.31 millions/cu mm 
Platelets: 53,000 cells/cu mm 

27/08/21
Hb - 11.6 gm/dl
TLC:  8,100 cells/cu mm 
Neutrophils: 20 % 
Lymphocytes: 73 % 
PCV - 33.4 vol %
MCV - 82.7 fl
MCHC - 34.7 %
MCH - 28.7 pg
RBC: 4.04 millions/cu mm 
Platelets: 95,000 cells/cu mm 

28/08/2021
Hb - 11.8 gm/dl
TLC: 7,600 cells/cu mm 
Neutrophils: 32 % 
Lymphocytes: 55 % 
PCV - 34 vol %
MCV - 82.9 fl
MCHC - 34.7 %
MCH - 28.8 pg
RBC: 4.10 millions/cu mm 
Platelets: 1.0 lakhs/cu mm

29/08/21
30/08/21
FEVER CHARTING

PROVISIONAL DIAGNOSIS :
VIRAL PYREXIA
 WITH THROMBOCYTOPENIA

TREATMENT GIVEN :
1. IVF: 500 ml 1 NS, & 1 RL@100ml/hr 
2. Plenty of oral fluids
3. Inj. PAN 40 mg/IV/OD  
4. Tab. Dolo 650mg/TID. 
5. Inj. NEOMOL 1gm/IV/SOS if temp > 101 F 
6. Inj ZOFER 4mg/iv/sos 
7. Watch for bleeding manifestations  
8.Temperature monitoring 4th hourly & tepid sponging
9. Postural B.P monitoring 

DAY 1 :
SOAP NOTES
SUBJECTIVE :
Fever
Giddiness
Pain abdomen

OBJECTIVE :
Temperature - 101 F
Bp
Supine - 80/50 mm hg
Standing - 90/60 mm hg
PR - 68 bpm
SPO2 - 98% at RA
GRBS - 124 mg/dl

Platelet - 53,000 cells/cumm

ASSESSMENT :
VIRAL PYREXIA WITH THROMBOCYTOPENIA

PLAN OF CARE :
1. IVF: 500 ml 1 NS, & 1 RL@100ml/hr 
2. Inj. PAN 40 mg/IV/OD  
3. Tab. Dolo 650mg/TID. 
4. Inj. NEOMOL 1gm/IV/SOS if temp > 101 F 
5. Inj ZOFER 4mg/iv/sos 
6. Watch for bleeding manifestations  
7.Temperature monitoring 4th hourly 
8. Postural B.P monitoring

DAY 2 :
SOAP NOTES
SUBJECTIVE :
Fever spikes absent
Pain abdomen
Burning micturition

OBJECTIVE :
Temperature - 97.7 F
Bp :
Supine - 90/60 mm hg
Standing - 80/60 mm hg
PR - 72 bpm
RR - 16 cpm
SPO2 - 98% at RA
GRBS - 92 mg/dl

Platelet - 95,000 cells/cumm

ASSESSMENT :
VIRAL PYREXIA WITH THROMBOCYTOPENIA

PLAN OF CARE :
1. IVF: 500 ml 1 NS, & 1 RL@100ml/hr 
2. Inj. PAN 40 mg/IV/BD
3. Tab. Dolo 650mg/TID. 
4. Inj. NEOMOL 1gm/IV/SOS if temp > 101 F 
5. Tab BUSCOPAN 10 mg PO/TID
6. Inj ZOFER 4mg/iv/sos 
7. Syp CITRALKA 10 ml in half glass of water TID
8. Watch for bleeding manifestations  
9.Temperature monitoring 4th hourly 
10. Daily postural B.P monitoring

DAY 3 :
SOAP NOTES
SUBJECTIVE :
Fever spikes absent
Pain abdomen decreased
Burning micturition resolved

OBJECTIVE :
Temperature - Afebrile
Bp :
Supine - 100/80 mm hg
Standing - 90/70 mm hg
PR - 68 bpm
RR - 16 cpm
SPO2 - 98% at RA
GRBS - 126 mg/dl

Platelet - 1 lakh cells/cumm

ASSESSMENT :
VIRAL PYREXIA WITH THROMBOCYTOPENIA

PLAN OF CARE :
1. IVF: 500 ml 1 NS, & 1 RL@100ml/hr 
2. Inj. PAN 40 mg/IV/BD
3. Tab. Dolo 650mg/sos
4. Inj. NEOMOL 1gm/IV/SOS if temp > 101 F 
5. Tab BUSCOPAN 10 mg PO/TID
6. Inj ZOFER 4mg/iv/sos 
7. Syp CITRALKA 10 ml in half glass of water TID
8. Watch for bleeding manifestations  
9.Temperature monitoring 4th hourly 
10. Daily postural B.P monitoring

DAY 4 :
SOAP NOTES
SUBJECTIVE :
Fever spikes absent
Pain abdomen resolved
Burning micturition resolved

OBJECTIVE :
Temperature - Afebrile
Bp :
Supine - 90/80 mm hg
Standing - 90/70 mm hg
PR - 68 bpm
RR - 16 cpm
SPO2 - 98% at RA
GRBS - 126 mg/dl

Platelet - 1.6 lakh cells/cumm

ASSESSMENT :
VIRAL PYREXIA WITH THROMBOCYTOPENIA

PLAN OF CARE :
1. IVF: 500 ml 1 NS, & 1 RL@100ml/hr 
2. Inj. PAN 40 mg/IV/BD
3. Tab. Dolo 650mg/sos
4. Inj. NEOMOL 1gm/IV/SOS if temp > 101 F 
5. Tab BUSCOPAN 10 mg PO/TID
6. Inj ZOFER 4mg/iv/sos 
7. Syp CITRALKA 10 ml in half glass of water TID
8. Watch for bleeding manifestations  
9.Temperature monitoring 4th hourly 
10. Daily postural B.P monitoring

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